Preparation of [18F]-NHC-BF3 conjugates and their applications in PET imaging
Author:
Affiliation:
1. Biomedical Research Imaging Center
2. Department of Radiology
3. University of North Carolina
4. Chapel Hill
5. USA 27514
6. Department of Chemistry
7. Texas A&M University
8. College Station
9. USA 77843
Abstract
[18F]-NHC-BF3 functionalized bioactive molecules can be successfully synthesized by 18F–19F isotopic exchange in one labelling step affording highly stable PET probes which can visualize targeted tumours in mice.
Funder
National Cancer Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA28806E
Reference26 articles.
1. [18F]-Group 13 fluoride derivatives as radiotracers for positron emission tomography
2. [18F]-Organotrifluoroborates as Radioprosthetic Groups for PET Imaging: From Design Principles to Preclinical Applications
3. Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography
4. Late-stage [18F]fluorination: new solutions to old problems
5. From Unorthodox to Established: The Current Status of 18F-Trifluoroborate- and 18F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging
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