Urease catalyzed high-density sodium alginate microspheres enable high oral bioavailability of macromolecular drugs-Reference-Cited by-同舟云学术

Urease catalyzed high-density sodium alginate microspheres enable high oral bioavailability of macromolecular drugs

Published:2024 Issue:6 Volume:12 Page:1515-1528
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Jiang Yicheng¹,Mi Li¹,Xu Xiang¹²,Hii Adric Ru Khiing¹,Wu Zhenghong¹^ORCID,Qi Xiaole¹³^ORCID

Affiliation:

1. Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, PR China

2. King's College London, Institution of Pharmaceutical Science, Franklin Wilkins Building, 150 Stamford St, London SE1 9NH, England, UK

3. Industrial Technology Innovation Platform, Zhejiang Center for Safety Study of Drug Substances, Hangzhou 310018, China

Abstract

The Ins/Ur/MgO@SA microsphere exhibits rapid settling in the stomach and deep penetration into the mucus layer via urease-catalyzed urea hydrolysis, thereby enhancing the bioavailability of macromolecular drugs by overcoming acid, enzyme, and mucus barriers in the gastric environment.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D3BM01715J

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