CPA-catalyzed asymmetric domino thia-Michael/aldol reactions for simultaneous chiral center and axial chirality formation-Reference-Cited by-同舟云学术

CPA-catalyzed asymmetric domino thia-Michael/aldol reactions for simultaneous chiral center and axial chirality formation

Published:2023 Issue:33 Volume:21 Page:6697-6701
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Xilong¹²,Luo Yu¹²,Zhao Jiaji³^ORCID,Luo Shuang¹²^ORCID

Affiliation:

1. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China

2. University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China

3. School of Medicine and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528400, China

Abstract

An efficient CPA-catalyzed enantio- and diastereo-selective domino thia-Michael/aldol reaction was developed, leading to a bridged biaryl adduct with multiple stereogenic centers and a thermodynamically controlled stereogenic axis.

Funder

Postdoctoral Research Foundation of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01087B

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1. Enantioselective Construction of Axially Chiral Amino Sulfide Vinyl Arenes by Chiral Sulfide‐Catalyzed Electrophilic Carbothiolation of Alkynes

2. Chiral Pd-Catalyzed Enantioselective Syntheses of Various N–C Axially Chiral Compounds and Their Synthetic Applications

3. Recent advances in the synthesis of axially chiral biarylsviatransition metal-catalysed asymmetric C–H functionalization

4. Construction of Axially Chiral Compounds via Central‐to‐Axial Chirality Conversion

5. Total synthesis of chiral biaryl natural products by asymmetric biaryl coupling