An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo-Reference-Cited by-同舟云学术

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

Published:2017 Issue:3 Volume:8 Page:2241-2250
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mayr Josef¹²³⁴,Heffeter Petra⁵⁶³⁴⁷,Groza Diana⁵⁶³⁴,Galvez Luis¹⁸³⁴,Koellensperger Gunda¹⁸³⁴,Roller Alexander¹²³⁴,Alte Beatrix¹²³⁴⁵,Haider Melanie⁵⁶³⁴,Berger Walter⁵⁶³⁴⁷,Kowol Christian R.¹²³⁴⁷^ORCID,Keppler Bernhard K.¹²³⁴⁷

Affiliation:

1. University of Vienna

2. Institute of Inorganic Chemistry

3. Vienna

4. Austria

5. Institute of Cancer Research and Comprehensive Cancer Center

6. Medical University of Vienna

7. Research Platform “Translational Cancer Therapy Research”

8. Institute of Analytical Chemistry

Abstract

An oxaliplatin-based platinum(iv) drug which specifically binds to albumin after i.v. application led to several complete responses in tumor-bearing mice.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03862J

Reference48 articles.

1. Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode

2. Platinum Antitumor Complexes: 50 Years Since Barnett Rosenberg's Discovery

3. Cisplatin resistance and opportunities for precision medicine

4. Platinum-based drugs: past, present and future

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