Efficient synthesis of cyclic amidine-based fluorophores via 6π-electrocyclic ring closure

Author:

Li Guofeng12345ORCID,Zhao Man12345,Xie Junqiu67895,Yao Ying12345,Mou Lingyun67895,Zhang Xiaowei67895,Guo Xiaomin67895,Sun Wangsheng67895ORCID,Wang Zheng101112135ORCID,Xu Jiecheng12345,Xue Jianzhong12345,Hu Tao12345,Zhang Ming67895,Li Min12345,Hong Liang12345ORCID

Affiliation:

1. Guangdong Key Laboratory of Chiral Molecular and Drug Discovery

2. School of Pharmaceutical Sciences

3. Sun Yat-Sen University

4. Guangzhou 510006

5. China

6. Key Laboratory of Preclinical Study for New Drugs of Gansu Province

7. School of Basic Medical Sciences

8. Lanzhou University

9. Lanzhou 730000

10. Guangdong Key Lab of Nano-Micro Material Research

11. School of Chemical Biology and Biotechnology

12. Peking University Shenzhen Graduate School

13. Shenzhen 518055

Abstract

Novel 10π-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6π-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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