Shortwave infrared fluorescence in vivo imaging of nerves for minimizing the risk of intraoperative nerve injury

Author:

Xu Heng12345,Chen Jun67845ORCID,Feng Zhujun9345,Fu Kan10111213,Qiao Yusen1415161713,Zhang Zheng12345,Wang Wenjin12345,Wang Yueming181945,Zhang Jian67845,Perdanasari Aurelia Trisliana202113,Hanasono Matthew M.22232113,Levin L. Scott2425261713,Yang Xing2728295ORCID,Hao Yuefeng2728295,Li Yunxia67845,Wo Yan9345,Zhang Yixin12345

Affiliation:

1. Department of Plastic and Reconstructive Surgery

2. Shanghai Ninth People's Hospital

3. Shanghai Jiao Tong University School of Medicine

4. Shanghai

5. China

6. Department of Orthopedic Sports Medicine

7. Huashan Hospital

8. Fudan University

9. Department of Anatomy and Physiology

10. Silicon Products Group

11. Applied Materials Inc.

12. Sunnyvale

13. USA

14. P. Roy and Diana T. Vagelos Laboratories

15. Department of Chemistry

16. University of Pennsylvania

17. Philadelphia

18. Department of Radiology

19. Fudan University Shanghai Cancer Center

20. Division of Plastic Surgery Baylor College of Medicine

21. Houston

22. Department of Plastic Surgery

23. the University of Texas MD Anderson Cancer Center

24. Division of Plastic Surgery

25. Department of Orthopaedic Surgery

26. Hospital of the University of Pennsylvania

27. Department of orthopedics

28. Affiliated Suzhou Hospital of Nanjing Medical University

29. Suzhou 215500

Abstract

A novel nerve specific imaging agent based on SWIR QD-based in vivo imaging can markedly minimize the risk of iatrogenic nerve injuries during surgeries by providing real-time and long-time SWIR images of peripheral nerves in specific.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Sanming Project of Medicine in Shenzhen

Shanghai Rising-Star Program

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Reference24 articles.

1. Accessory Nerve Injury: Conservative or Surgical Treatment?

2. S. Hyun Park , Y.Esquenazi , D.Kline and D. H.Kim , Surgical outcomes of 156 spinal accessory nerve injuries caused by lymph node biopsy procedures , 2015

3. Surgical treatment for spinal accessory nerve injury

4. D. H. Kim , Y.-J.Cho , R. L.Tiel and D.Kline , Surgical Outcomes of 111 Spinal Accessory Nerve Injuries , 2003

5. Chronic post-surgical pain: 10 years on

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