One-step synthesis of favipiravir from Selectfluor® and 3-hydroxy-2-pyrazinecarboxamide in an ionic liquid-Reference-Cited by-同舟云学术

One-step synthesis of favipiravir from Selectfluor® and 3-hydroxy-2-pyrazinecarboxamide in an ionic liquid

Published:2023 Issue:17 Volume:21 Page:3660-3668
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fuentes Germán¹,García María F.²,Cerecetto Hugo¹²,Álvarez Guzmán³,Couto Marcos¹,Romero Angel H.¹^ORCID

Affiliation:

1. Grupo de Química Orgánica Medicinal, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay

2. Area de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Mataojo 2055, 11400 Montevideo, Uruguay

3. Laboratorio de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, 60000 Paysandú, Uruguay

Abstract

A novel efficient one-step synthetic strategy for the preparation of the antiviral favipiravir from with the available 3-hydroxy-2-pyrazinecarboxamide and Selectfluor® was developed, the use of an IL being essential.

Funder

Comisión Sectorial de Investigación Científica

Sistema Nacional de Investigadores

Universidad de la República Uruguay

Agencia Nacional de Investigación e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00380A

Reference32 articles.