Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA-Reference-Cited by-同舟云学术

Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA

Published:2021 Issue:15 Volume:12 Page:5419-5429
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lin Yu¹²³⁴⁵^ORCID,Wu Kui⁶⁷⁸⁹¹⁰^ORCID,Jia Feifei¹²³⁴⁵^ORCID,Chen Ling¹²³⁴⁵,Wang Zhaoying¹²³⁴⁵,Zhang Yanyan¹²³⁴⁵^ORCID,Luo Qun¹²³⁴⁵,Liu Suyan¹²³⁴⁵,Qi Luyu¹²³⁴⁵,Li Nan¹¹¹²¹⁰¹²,Dong Pu¹³¹²¹⁰,Gao Fei¹³¹²¹⁰,Zheng Wei¹²³⁴⁵,Fang Xiaohong¹¹¹²¹⁰¹²^ORCID,Zhao Yao¹²³⁴⁵^ORCID,Wang Fuyi¹²³⁴⁵^ORCID

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. CAS Research/Education Center for Excellence in Molecular Sciences

3. National Centre for Mass Spectrometry in Beijing

4. CAS Key Laboratory of Analytical Chemistry for Living Biosystems

5. Institute of Chemistry

6. Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials

7. School of Chemistry and Chemical Engineering

8. Wuhan University of Science and Technology

9. Wuhan

10. People's Republic of China

11. University of Chinese Academy of Sciences

12. Beijing

13. China Telecom Corporation Limited Beijing Research Institute

Abstract

A dual-modal microscopy imaging strategy was developed to investigate in situ the interactions between transcription (co)factors with cisplatin damaged DNA in single cells, showing that cisplatin lesions disrupted the interactions of Smad3 with DNA.

Funder

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Natural Science Foundation of Beijing Municipality

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06760A

Reference50 articles.