Tether-free optogenetic control of insulin secretion using an upconversion nanoparticle-doped hydrogel platform-Reference-Cited by-同舟云学术

Tether-free optogenetic control of insulin secretion using an upconversion nanoparticle-doped hydrogel platform

Published:2023 Issue:6 Volume:11 Page:2046-2055
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Bansal Akshaya¹,Zhang Jing²,Lu Qi³,Mei Qingsong³^ORCID,Zhang Yong¹⁴^ORCID

Affiliation:

1. Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117576, Singapore

2. School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

3. Department of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, Guangdong 510632, China

4. NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore 117456, Singapore

Abstract

Upconversion nanoparticles and optogenetic-engineered cells are co-encapsulated to construct a smart hydrogel platform, allowing deep tissue-penetrating towards implementation a tether-free optogenetic gene expression of GLP-1 for diabetes.

Funder

Ministry of Education - Singapore

National Medical Research Council

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01890J

Reference23 articles.

1. Delivery of Therapeutic Proteins

2. Membrane‐Penetrating Carbon Quantum Dots for Imaging Nucleic Acid Structures in Live Organisms

3. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

4. Protein–protein interactions as targets for small-molecule therapeutics in cancer

5. The Future of Peptide-based Drugs

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