Chiral bifunctional organocatalysts for enantioselective synthesis of 3-substituted isoindolinones-Reference-Cited by-同舟云学术

Chiral bifunctional organocatalysts for enantioselective synthesis of 3-substituted isoindolinones

Published:2023 Issue:35 Volume:13 Page:24460-24465
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Hu Xiao-Mu¹²,Zhang Rui¹,Dong Hai¹,Jia Yan-Yan³,Bao Guo-Qiang⁴,Wang Ping-An¹^ORCID

Affiliation:

1. School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China

2. Department of Pharmacy, The 900 Hosipital of PLA, Fuzhou, Fujian, China

3. Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China

4. Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China

Abstract

Chiral tertiary-amine catalysts with a urea group can afford 3-substituted isoindolinones both in higher yields (87% vs. 77%) and enantioselectivities (95% ee vs. 46% ee) than chiral bifunctional phase-transfer catalysts under mild conditions.

Funder

National Natural Science Foundation of China

Fourth Military Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA04350A

Reference33 articles.

1. An Efficient and Cost-Effective Synthesis of Pagoclone

2. Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde

3. A Versatile Approach for the Asymmetric Synthesis of 3-Alkyl-isoindolin-1-ones

4. A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets

5. Alumina‐Supported Alkali and Alkaline Earth Metal‐Based Catalyst for Selective Decarboxylation of Itaconic Acid to Methacrylic Acid

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