5-Carboxylcytosine is resistant towards phosphodiesterase I digestion: implications for epigenetic modification quantification by mass spectrometry-Reference-Cited by-同舟云学术

5-Carboxylcytosine is resistant towards phosphodiesterase I digestion: implications for epigenetic modification quantification by mass spectrometry

Published:2019 Issue:50 Volume:9 Page:29010-29014
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yuan Fang¹²³⁴⁵^ORCID,Bi Ying¹²³⁴⁵^ORCID,Zhang Jia-Yuan¹²³⁴⁵^ORCID,Zhou Ying-Lin⁶⁷⁸⁹¹⁰^ORCID,Zhang Xin-Xiang⁶⁷⁸⁹¹⁰,Song Chun-Xiao¹²³⁴⁵^ORCID

Affiliation:

1. Ludwig Institute for Cancer Research

2. Target Discovery Institute

3. Nuffield Department of Medicine

4. University of Oxford

5. UK

6. Beijing National Laboratory for Molecular Sciences (BNLMS)

7. MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering

8. College of Chemistry

9. Peking University

10. Beijing 100871

Abstract

5-Carboxylcytosine is found to be resistant to snake venom phosphodiesterase I (PDE1), a 3′ to 5′ exonuclease commonly used in several DNA hydrolysis protocols.

Funder

Cancer Research UK

Conrad N. Hilton Foundation

NIHR Oxford Biomedical Research Centre

Ludwig Institute for Cancer Research

China Scholarship Council

University of Oxford

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA04375F

Reference34 articles.

1. Genomic DNA methylation: the mark and its mediators

2. DNA Methylation in Mammals

3. The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

4. Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

5. Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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