Solution structure of a thrombin binding aptamer complex with a non-planar platinum(<scp>ii</scp>) compound-Reference-Cited by-同舟云学术

Solution structure of a thrombin binding aptamer complex with a non-planar platinum(ii) compound

Published:2022 Issue:28 Volume:13 Page:8371-8379
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhu Bo-Chen¹,He Juan²,Xia Xiao-Yu¹,Jiang Jingxing³,Liu Wenting¹^ORCID,Liu Liu-Yi¹^ORCID,Liang Bing-Bing¹,Yao Hua-Gang²,Ke Zhuofeng³^ORCID,Xia Wei¹^ORCID,Mao Zong-Wan¹^ORCID

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China

2. School of Pharmaceutical and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, China

3. School of Materials Science and Engineering, PCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China

Abstract

A quasi-cross-shaped platinum(II) compound (L′2LPt) with inhibitory activity against thrombin binds the antiparallel two-G-tetrad G-quadruplex TBA. The NMR structure of the Pt–G-quadruplex was solved to reveal this unusual “wall-mounted” binding mode.

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Science and Technology Planning Project of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01196D

Reference56 articles.

1. HELIX FORMATION BY GUANYLIC ACID