Splitting a DNAzyme enables a Na+-dependent FRET signal from the embedded aptamer
Author:
Affiliation:
1. Xiangya School of Pharmaceutical Sciences
2. Central South University
3. Changsha
4. China
5. Department of Chemistry
6. Waterloo Institute for Nanotechnology
7. University of Waterloo
8. Waterloo
9. Canada
Abstract
The Na+-specific Ce13d DNAzyme is rigid showing no global folding in the presence of Na+, but splitting it at the cleavage site enables its Na+-specific folding detected by FRET.
Funder
Natural Sciences and Engineering Research Council of Canada
China Scholarship Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01709J
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5. Biochemical and biophysical understanding of metal ion selectivity of DNAzymes
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