Process integrated biosensors for real-time monitoring of antibodies for automated affinity purification-Reference-Cited by-同舟云学术

Process integrated biosensors for real-time monitoring of antibodies for automated affinity purification

Published:2022 Issue:44 Volume:14 Page:4555-4562
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Tran Thuy¹,Martinsson Erik²,Gustavsson Robert³,Tronarp Otto⁴,Nilsson Mats⁵,Hansson Kristoffer Rudenholm⁵,Lundström Ingemar⁶,Mandenius Carl-Fredrik³,Aili Daniel¹^ORCID

Affiliation:

1. Laboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, Linköping 581 83, Sweden

2. ArgusEye AB, Spannmålsgatan 55, Linköping 583 36, Sweden

3. Biotechnology, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, Linköping 581 83, Sweden

4. Wolfram MathCore AB, Teknikringen 1E, Linköping 583 30, Sweden

5. BioInvent International AB, Ideon Science Park, Lund 223 70, Sweden

6. Sensor and Actuator Systems, Department of Physics, Chemistry and Biology, Linköping University, Linköping 581 83, Sweden

Abstract

A sensor technology for in-line detection of monoclonal antibodies (mAbs) in affinity capture steps is demonstrated. Continuous mAb monitoring during multiple consecutive purification cycles can facilitate automatization and continuous processing.

Funder

H2020 Marie Skłodowska-Curie Actions

VINNOVA

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AY/D2AY01567F

Reference28 articles.

1. Therapeutic monoclonal antibodies

2. Development of therapeutic antibodies for the treatment of diseases

3. Recent Advances and Future Directions in Downstream Processing of Therapeutic Antibodies

4. Protein A chromatography for antibody purification

5. Downstream processing of monoclonal antibodies—Application of platform approaches

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