Few-layered graphene increases the response of nociceptive neurons to irritant stimuli

Author:

Deleye Lieselot1,Franchi Francesca12,Trevisani Martina13,Loiacono Fabrizio2ORCID,Vercellino Silvia12ORCID,Debellis Doriana4,Liessi Nara5,Armirotti Andrea5,Vázquez Ester6ORCID,Valente Pierluigi23ORCID,Castagnola Valentina12ORCID,Benfenati Fabio12ORCID

Affiliation:

1. Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia (IIT), Largo Rosanna Benzi 10, 16132 Genova, Italy

2. IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy

3. Department of Experimental Medicine, Section of Physiology, University of Genova, Genoa, 16132, Italy

4. Electron Microscopy Facility, IIT, Via Morego 30, 16163, Genoa, Italy

5. Analytical Chemistry Facility, IIT, via Morego, 30, 16163, Genoa, Italy

6. Facultad de Ciencias Químicas, Universidad Castilla La-Mancha, Ciudad Real, 13071 Spain

Abstract

Few-layered graphene (FLG) treatment increases the functional response of the nociceptive subpopulation of sensory neurons of the dorsal root ganglia (DRG) in response to irritants specific for chemoreceptors TRPV1 and TRPA1.

Funder

Graphene Flagship

Ministero degli Affari Esteri e della Cooperazione Internazionale

Publisher

Royal Society of Chemistry (RSC)

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