Multi-gram scale synthesis of a bleomycin (BLM) carbohydrate moiety: exploring the antitumor beneficial effect of BLM disaccharide attached to 10-hydroxycamptothecine (10-HCPT)-Reference-Cited by-同舟云学术

Multi-gram scale synthesis of a bleomycin (BLM) carbohydrate moiety: exploring the antitumor beneficial effect of BLM disaccharide attached to 10-hydroxycamptothecine (10-HCPT)

Published:2019 Issue:15 Volume:43 Page:6010-6020
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Li MaoLin¹²³⁴⁵,Huang Weiping¹²³⁴⁵,Jiang Zhilin⁶⁷⁸⁹¹⁰,Shi Yonghui¹¹¹²¹³¹⁴⁹,Yuan Sisi¹²³⁴⁵,Fu Kaishuo¹²³⁴⁵,Chen YongJun¹⁵¹⁶²³⁴,Zhou Li¹⁷¹⁸¹⁹⁹,Zhou Wen¹²³⁴⁵^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Guangzhou University of Chinese Medicine

3. University Town

4. Waihuan Rd

5. Panyu

6. Puer University

7. Puer

8. Yunan

9. China

10. Institute of Comparative Study of Traditional Material Medica

11. Department of Pharmacy

12. Sun Yat-Sen Memorial Hospital

13. Sun Yat-Sen University

14. Guangzhou

15. South China Research Centre for Acupuncture and Moxibustion

16. Medical College of Acu-Moxi and Rehabilitation

17. College of Science

18. Hunan Agricultural University

19. Changsha

Abstract

An efficient multi-gram synthesis of bleomycin disaccharide has been developed, and its conjugate with 10-HCPT displayed obvious selectivity, clearly indicating the potential of bleomycin disaccharide in solving the targeted therapy of cytotoxic drugs.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C8NJ06191B

Reference26 articles.

1. Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber

2. Application of Mono- and Disaccharides in Drug Targeting and Efficacy

3. Solid-Phase Synthesis of Bleomycin A5 and Three Monosaccharide Analogues: Exploring the Role of the Carbohydrate Moiety in RNA Cleavage