One-pot synthesis of natural-product inspired spiroindolines with anti-cancer activities-Reference-Cited by-同舟云学术

One-pot synthesis of natural-product inspired spiroindolines with anti-cancer activities

Published:2022 Issue:3 Volume:9 Page:682-686
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Shi-Qiang¹,Yan Wei²³,He Liu-Jun¹,Zhang Ming⁴,Tang Dian-Yong¹^ORCID,Li Hong-yu²,Chen Zhong-Zhu¹,Xu Zhi-Gang¹^ORCID

Affiliation:

1. College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

3. Department of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

4. Cancer Center, Academy of Medical Sciences and Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and technology of China, Chengdu, Sichuan 610000, China

Abstract

A post-Ugi/diastereoselective cascade reaction was developed to construct the spiroindoline scaffold through a 5-exo-dig indole cyclization and the intramolecular trapping of the spiro intermediate forming a quaternary carbon center.

Funder

Chongqing Municipal Education Commission

Department of Science and Technology of Sichuan Province

Natural Science Foundation of Chongqing

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01694F

Reference38 articles.

1. Green chemistry aspects of fluorous techniques—opportunities and challenges for small-scale organic synthesis