A variety of roles for versatile zinc in metallo-β-lactamases-Reference-Cited by-同舟云学术

A variety of roles for versatile zinc in metallo-β-lactamases

Published:2014 Issue:7 Volume:6 Page:1181-1197
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Karsisiotis A. I.¹²³,Damblon C. F.⁴⁵⁶⁷,Roberts G. C. K.⁸⁹¹⁰¹¹

Affiliation:

1. School of Biological Sciences

2. University of Essex

3. Colchester, UK

4. Chimie Biologique Structurale

5. Institut de Chimie

6. Université de Liège

7. 4000 Liège, Belgium

8. The Henry Wellcome Laboratories of Structural Biology

9. Department of Biochemistry

10. University of Leicester

11. Leicester LE1 9HN, UK

Abstract

β-Lactamases inactivate the important β-lactam antibiotics by catalysing the hydrolysis of the β-lactam ring, thus. One class of these enzymes, the metallo-β-lactamases, bind two zinc ions at the active site and these play important roles in the catalytic mechanism.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MT/C4MT00066H

Reference128 articles.

1. β-Lactamases: A Survey of Protein Diversity

2. Molecular analysis of beta-lactamase structure and function

3. Metallo-β-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily

4. Metallo-β-lactamase structure and function

5. Zinc as a Cofactor for Cephalosporinase from Bacillus cereus 569

Cited by 61 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Metallo-β-lactamases;Metalloenzymes;2024

2. Characterization of an N-acylhomoserine lactonase from Serratia sp. and its biofouling mitigation in a membrane bioreactor;Microbiological Research;2022-11

3. Inhibiting the metallo-β-lactamases: challenges and strategies to overcome bacterial β-lactam resistance;Future Medicinal Chemistry;2022-07

4. Multi Evaluation of a Modified GoldNano Carb Test for Carbapenemase Detection in Clinical Isolates of Gram-Negative Bacilli;Antibiotics;2022-05-18

5. Structure and Mechanism-Guided Design of Dual Serine/Metallo-Carbapenemase Inhibitors;Journal of Medicinal Chemistry;2022-04-14