Genistein promotes the metabolic transformation of acetaminophen to glucuronic acid in human L-O2, HepG2 and Hep3b cells via the Nrf2/Keap1 pathway-Reference-Cited by-同舟云学术

Genistein promotes the metabolic transformation of acetaminophen to glucuronic acid in human L-O2, HepG2 and Hep3b cells via the Nrf2/Keap1 pathway

Published:2016 Issue:11 Volume:7 Page:4683-4692
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yuan-jing Fan¹²³⁴^ORCID,Wei Wei¹²³⁴,Jian-ping Luo¹²³⁴,Yu-xia Jin¹²³⁴,Zi-ling Dai¹²³⁴

Affiliation:

1. School of Food science and Engineering

2. Hefei University of Technology

3. Hefei 230009

4. China

Abstract

Genistein can prevent and protect against APAP-induced liver toxicity due to the inhibition of APAP biotransformation and the resistance to oxidative stress.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2016/FO/C6FO00889E

Reference34 articles.

1. Comparison of Flavonoids and Isoflavonoids as Antioxidants

2. Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism

3. Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes

4. Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice

5. The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

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