Structure–function–dynamics of α-chymotrypsin based conjugates as a function of polymer charge
Author:
Affiliation:
1. Department of Chemistry
2. University of Florida
3. Gainesville
4. USA
5. George and Josephine Butler Polymer Research Laboratory
6. Department of Biomedical Engineering
7. Scott Hall 4N201
8. Carnegie Mellon University
9. Pittsburgh
Abstract
Atomistic molecular dynamics simulations improve our understanding of protein–polymer conjugates, and can predict how charged polymers affect the native dynamics of the protein.
Funder
University of Florida
Publisher
Royal Society of Chemistry (RSC)
Subject
Condensed Matter Physics,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/SM/C9SM01842E
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1. Unraveling Binding Interactions between Human RANKL and Its Decoy Receptor Osteoprotegerin
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4. Polymer therapeutics—polymers as drugs, drug and protein conjugates and gene delivery systems: Past, present and future opportunities
5. FDA-approved poly(ethylene glycol)–protein conjugate drugs
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