2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants-Reference-Cited by-同舟云学术

2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants

Published:2019 Issue:3 Volume:10 Page:431-438
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Pirotte Bernard¹²³⁴⁵^ORCID,Florence Xavier¹²³⁴⁵,Goffin Eric¹²³⁴⁵,Lebrun Philippe⁶⁷⁸⁹¹⁰

Affiliation:

1. Laboratoire de Chimie Pharmaceutique

2. Center for Interdisciplinary Research on Medicines (CIRM)

3. Université de Liège

4. Quartier Hôpital

5. B-4000 Liège

6. Laboratoire de Physiologie et Pharmacologie

7. Université Libre de Bruxelles

8. Faculté de Médecine

9. B-1070 Bruxelles

10. Belgium

Abstract

The present study describes the synthesis and biological evaluation of 4-phenylureido/thioureido-substituted 2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of corresponding 2,2-dimethylchromans reported as K_ATP channel openers.

Funder

Fonds De La Recherche Scientifique - FNRS

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00593A

Reference36 articles.

1. Adenosine 5'-Triphosphate-Sensitive Potassium Channels

2. The Sulfonylurea Receptor, an Atypical ATP-Binding Cassette Protein, and Its Regulation of the KATPChannel

3. KATP channels as molecular sensors of cellular metabolism

4. Intracellular ATP directly blocks K+ channels in pancreatic B-cells

5. ATP-Sensitive Potassium Channels: Structures, Functions, and Pathophysiology

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