Diastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes

Author:

Beebe Alexander W.1234,Dohmeier Emma F.5234,Moura-Letts Gustavo1234

Affiliation:

1. Department of Chemistry and Biochemistry

2. Rowan University

3. New Jersey

4. USA

5. Department of Chemical Engineering

Abstract

Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method provides a wide variety of substituted diaziridines with high yields and diastereoselectivities.

Funder

American Chemical Society Petroleum Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference31 articles.

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2. The Chemistry of Heterocycles, ed. T. Eicher and S. Hauptmann, Wiley-VCH, 2005

3. The Chemistry of Transition Metals with Three-Membered Ring Heterocycles

4. Diazirines:  Carbene Precursors Par Excellence

5. Catalytic Diamination of Olefins via N–N Bond Activation

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