The multi-channel reaction of the OH radical with 5-hydroxymethylcytosine: a computational study-Reference-Cited by-同舟云学术

The multi-channel reaction of the OH radical with 5-hydroxymethylcytosine: a computational study

Published:2016 Issue:16 Volume:6 Page:13349-13357
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Jin Lingxia¹²³⁴⁵,Zhao Caibin¹²³⁴⁵,Liu Cunfang¹²³⁴⁵,Min Suotian¹²³⁴⁵,Zhang Tianlei¹²³⁴⁵,Wang Zhiyin¹²³⁴⁵,Wang Wenliang⁶⁷⁸⁹¹⁰,Zhang Qiang¹²³⁴⁵

Affiliation:

1. Shaanxi Province Key Laboratory of Catalytic Fundamentals & Applications

2. Shaanxi Key Laboratory for Resource Biology

3. Vitamin D Research Institute

4. School of Chemical & Environment Science

5. Shaanxi University of Technology

6. Key Laboratory for Macromolecular Science of Shaanxi Province

7. School of Chemistry and Chemical Engineering

8. Shaanxi Normal University

9. Xi’an 710062

10. China

Abstract

The hydroxyl radical may attack the new cytosine derivative 5-hydroxymethylcytosine (5-hmCyt), causing DNA oxidative damage. Two distinct mechanisms have been explored and our results provide some evidence between 5-hmCyt and tumor development.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA24293B

Reference52 articles.

1. Pattern of hydroxyl radical addition to cytosine and 1-, 3-, 5-, and 6-substituted cytosines. Electron transfer and dehydration reactions of the hydroxyl adducts

2. How Easily Oxidizable Is DNA? One-Electron Reduction Potentials of Adenosine and Guanosine Radicals in Aqueous Solution

3. Theoretical Investigation of Adenine Radicals Generated in Irradiated DNA Components

4. Reaction of HO. with Guanine Derivatives in Aqueous Solution: Formation of Two Different Redox-Active OH-Adduct Radicals and Their Unimolecular Transformation Reactions. Properties of G(-H).

5. Biological consequences of free radical-damaged DNA bases1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

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