Dual stimulus-triggered bioorthogonal nanosystem for spatiotemporally controlled prodrug activation and near-infrared fluorescence imaging-Reference-Cited by-同舟云学术

Dual stimulus-triggered bioorthogonal nanosystem for spatiotemporally controlled prodrug activation and near-infrared fluorescence imaging

Published:2023 Issue:26 Volume:59 Page:3878-3881
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhao Zhongyi¹,Zong Qingyu²,Li Jun³,Jiang Maolin⁴,Wang Kewei⁴,Yuan Youyong²⁴⁵^ORCID

Affiliation:

1. School of Medicine, South China University of Technology, Guangzhou, 510006, P. R. China

2. National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, P. R. China

3. Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, P. R. China

4. School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, P. R. China

5. Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510006, P. R. China

Abstract

Herein, we developed a dual stimulus-triggered bioorthogonal nanosystem that combines low pH and cathepsin B-triggered delivery carriers with a bioorthogonal reaction-activated prodrug and fluorescent probe to enhance tumor therapy and imaging.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Guangzhou Municipal Science and Technology Project

Basic and Applied Basic Research Foundation of Guangdong Province

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC00177F

Reference21 articles.

1. Progress, challenges, and future of nanomedicine

2. A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

3. Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

4. Unleashing the Power of Bond Cleavage Chemistry in Living Systems

5. Stimulus-responsive self-assembled prodrugs in cancer therapy

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