Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma-Reference-Cited by-同舟云学术

Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma

Published:2022 Issue:26 Volume:13 Page:7846-7854
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhou Le-Le¹,Guan Qun¹^ORCID,Zhou Wei²^ORCID,Kan Jing-Lan¹,Dong Yu-Bin¹^ORCID

Affiliation:

1. College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China

2. Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

Abstract

An iminium-linked cationic covalent organic framework-based nanoagent that is synthesized under ambient conditions achieves synergistic RNA interference and metabolic therapy via effective siRNA delivery and timely lysosome escape.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02297D

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1. Drug delivery systems for RNA therapeutics

2. Environment‐Responsive Lipid/siRNA Nanoparticles for Cancer Therapy