Design, synthesis, biological evaluation and molecular modelling studies of oxoacetamide warhead containing indole-quinazolinone based novel hybrid analogues as potential pancreatic lipase inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, biological evaluation and molecular modelling studies of oxoacetamide warhead containing indole-quinazolinone based novel hybrid analogues as potential pancreatic lipase inhibitors

Published:2022 Issue:24 Volume:46 Page:11648-11661
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Auti Prashant S.¹^ORCID,Nandi Arijit¹^ORCID,Kumari Vijeta¹^ORCID,Paul Atish T.¹^ORCID

Affiliation:

1. Laboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani (BITS Pilani), Pilani Campus, Pilani – 333031, Rajasthan, India

Abstract

A novel series of indolyl oxoacetamide-quinazolinone hybrid analogues (9aa–9df) were designed, synthesized, and evaluated for their in vitro pancreatic lipase (PL) inhibitory potential that may lead to efficient anti-obesity agents.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ01210C

Reference33 articles.

1. The Obesity Epidemic: Pathophysiology and Consequences of Obesity

2. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation

3. Obesity and overweight, https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight , accessed 3 March 2022