Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ<sub>42</sub> oligomers by controlling their interactions with cell membranes-Reference-Cited by-同舟云学术

Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ₄₂ oligomers by controlling their interactions with cell membranes

Published:2022 Issue:43 Volume:13 Page:12818-12830
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yu Zhengxin¹^ORCID,Guo Weijie²^ORCID,Patel Shrey¹,Cho Hong-Jun¹,Sun Liang¹,Mirica Liviu M.¹³^ORCID

Affiliation:

1. Department of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA

2. Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA

3. Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA

Abstract

Amphiphilic compounds with selectivity towards soluble Aβ42 oligomers were developed. Cell imaging studies show the compounds can reduce the interactions between Aβ42 oligomers and SH-SY5Y cell membranes, both in the presence and absence of Cu.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02654F

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