A microfluidic approach for experimentally modelling the intercellular coupling system of a mammalian circadian clock at single-cell level-Reference-Cited by-同舟云学术

A microfluidic approach for experimentally modelling the intercellular coupling system of a mammalian circadian clock at single-cell level

Published:2020 Issue:7 Volume:20 Page:1204-1211
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Han Kui¹²³⁴⁵,Mei Long⁶⁷⁵⁸⁹^ORCID,Zhong Ruoyu¹⁰¹¹⁵⁸⁹,Pang Yuhong¹²³⁴⁵,Zhang Eric Erquan¹²¹³⁹¹⁴¹⁵,Huang Yanyi¹²³⁴⁵^ORCID

Affiliation:

1. Biomedical Pioneering Innovation Center (BIOPIC)

2. Beijing Advanced Innovation Center for Genomics (ICG)

3. College of Engineering

4. College of Chemistry, and Peking-Tsinghua Center for Life Sciences

5. Peking University

6. PTN Joint Graduate Program

7. School of Life Sciences

8. Beijing 100871

9. China

10. Integrated Science Program

11. Yuanpei College

12. National Institute of Biological Sciences

13. Beijing 102206

14. Tsinghua Institute of Multidisciplinary Biomedical Research

15. Tsinghua University

Abstract

A proof-of-concept platform to reconstitute the intercellular coupling system of the central clock using uncoupled, single fibroblast cells in vitro, to mimic SCN slice cultures ex vivo and mouse behavior in vivo phenotypically.

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/D0LC00140F

Reference30 articles.

1. Transplanted Suprachiasmatic Nucleus Determines Circadian Period

2. Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

3. Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus

4. A model of the cell-autonomous mammalian circadian clock

5. Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network

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