Uniform trehalose nanogels for glucagon stabilization

Author:

Puente Ellie G.12ORCID,Sivasankaran Rajalakshmi P.12,Vinciguerra Daniele12ORCID,Yang Jane12,Lower Haillie-Ann C.12,Hevener Andrea L.34,Maynard Heather D.12ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, USA

2. California Nanosystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, USA

3. Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine University of California, Los Angeles, Los Angeles, CA, USA

4. Department of Medicine and VA Greater Los Angeles Healthcare System GRECC, Los Angeles, CA, 90073 USA

Abstract

Uniform trehalose nanogels improve stability and solubility of glucagon in aqueous solution, particularly useful for long term storage at cold temperatures. Additionally, the glucagon nanogels were nontoxic, nonhemolytic, and efficacious in vitro.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Royal Society of Chemistry (RSC)

Reference67 articles.

1. CDC, Low Blood Sugar (Hypoglycemia), https://www.cdc.gov/diabetes/basics/low-blood-sugar.html

2. CDC, How to Treat Low Blood Sugar (Hypoglycemia), https://www.cdc.gov/diabetes/basics/low-blood-sugar-treatment.html

3. Hypoglycemia

4. Glucagon & Other Emergency Glucose Products|ADA, https://diabetes.org/healthy-living/medication-treatments/glucagon-other-emergency-glucose-products

5. A combined activation mechanism for the glucagon receptor

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