Metabolic responses in the cortex and hippocampus induced by Il-15rα mutation

Author:

He Yi1,Ge Lijun2,Tong Fang3,Zheng Peng45,Yang Jian16,Zhou Jingjing16,Sun Zuoli1,Wang Haixia1,Yang Shun7,Li Yifan45,Yu Yuxin8ORCID

Affiliation:

1. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China

2. Liyuan Cardiovascular Center, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China

3. Department of Physiology and Biochemistry, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China

4. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

5. NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

6. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China

7. Department of General Surgery, Yantian District People's Hospital, Shenzhen, 518081, China

8. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

Abstract

Metabolomics showed distinct metabolic phenotypes of the different brain regions related to the IL-15 system, enhancing our understanding of the IL-15 system and its interactions with neuropsychiatric disorders.

Funder

National Natural Science Foundation of China

Chongqing Science and Technology Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

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