Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent-Reference-Cited by-同舟云学术

Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent

Published:2015 Issue:13 Volume:13 Page:4031-4040
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Thurston David E.¹²³,Vassoler Higia⁴⁵⁶³,Jackson Paul J. M.¹²³,James Colin H.⁴⁵⁶³,Rahman Khondaker M.¹²³

Affiliation:

1. Institute of Pharmaceutical Science

2. London SE1 1DB

3. UK

4. UCL School of Pharmacy

5. University College London

6. London WC1N 1AX

Abstract

Pyrrolobenzodiazepine (PBD) monomer GWL-78 reacts faster with DNA hairpins containing a hexaethylene glycol (HEG) loop compared to hairpins containing a TTT loop due to the greater structural flexibility of the HEG.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02405B

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3. Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

4. D. E. Thurston , in Molecular Aspects of Anticancer Drug-DNA Interactions, ed. S. Neidle and M. J. Waring, The Macmillan Press Ltd., London, UK, 1993, vol. 1, pp. 54–88

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