A novel 3D indirect co-culture system based on a collagen hydrogel scaffold for enhancing the osteogenesis of stem cells

Author:

Kim Hyerim12345,Han Shi Huan67345ORCID,Kook Yun-Min891045,Lee Kyung-Mee61145,Jin Yuan-Zhe12131415,Koh Won-Gun161745ORCID,Lee Jae Hyup67345,Lee Kangwon12345ORCID

Affiliation:

1. Program in Nanoscience and Technology

2. Graduate School of Convergence Science and Technology

3. Seoul National University

4. Seoul

5. Korea

6. Department of Orthopedic Surgery

7. College of Medicine

8. Center for Biomaterials

9. Biomedical Research Institute

10. Korea Institute of Science and Technology (KIST)

11. SMG-SNU Boramae Medical Center

12. Department of Spine Surgery

13. The First Hospital of Jilin University

14. Changchun

15. China

16. Department of Chemical and Biomolecular Engineering

17. Yonsei University

Abstract

In this study, the paracrine effect between adipose-derived mesenchymal stem cells (ADSCs) and osteoblasts was investigated in collagen-based three-dimensional (3D) scaffolds.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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