Antiurease screening of alkyl chain-linked thiourea derivatives: <i>in vitro</i> biological activities, molecular docking, and dynamic simulations studies-Reference-Cited by-同舟云学术

Antiurease screening of alkyl chain-linked thiourea derivatives: in vitro biological activities, molecular docking, and dynamic simulations studies

Published:2022 Issue:10 Volume:12 Page:6292-6302
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yaqoob Sana¹,Hameed Abdul¹²^ORCID,Ahmed Mahmood³^ORCID,Imran Muhammad⁴^ORCID,Qadir Muhammad Abdul⁵,Ramzan Mahwish⁶,Yousaf Numan⁶,Iqbal Jamshed⁷,Muddassar Muhammad⁶^ORCID

Affiliation:

1. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

2. Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

3. Department of Chemistry, Division of Science and Technology, University of Education, College Road, Lahore, Pakistan

4. KAM-School of Life Sciences, FC College (A Chartered University), Lahore, Pakistan

5. School of Chemistry, University of the Punjab, Lahore, Pakistan

6. Department of Biosciences, COMSATS University Islamabad, Park Road, Islamabad, Pakistan

7. Center for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan

Abstract

Urease has become an important therapeutic target because it stimulates the pathogenesis of many human health conditions, such as pyelonephritis, the development of urolithiasis, hepatic encephalopathy, peptic ulcers, gastritis and gastric cancer.

Funder

Higher Education Commision, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA08694D

Reference31 articles.

1. Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors

2. 3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation

3. Long chain 1-acyl-3-arylthioureas as jack bean urease inhibitors, synthesis, kinetic mechanism and molecular docking studies

4. Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies

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