An electrochemical sensor based on DNA polymerase and HRP-SiO2 nanoparticles for the ultrasensitive detection of K-ras gene point mutation-Reference-Cited by-同舟云学术

An electrochemical sensor based on DNA polymerase and HRP-SiO2 nanoparticles for the ultrasensitive detection of K-ras gene point mutation

Published:2016 Issue:11 Volume:6 Page:8669-8676
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhao Chengfei¹²³⁴,Gao Feng⁵⁶⁷⁴,Weng Shaohuang⁸⁹¹⁰¹¹⁴,Liu Qicai¹²⁶⁷⁴,Lin Liqing⁸⁹¹⁰¹¹⁴,Lin Xinhua⁸⁹¹⁰¹¹⁴

Affiliation:

1. Pharmaceutical and Medical Technology College

2. Putian University

3. Putian 351100

4. China

5. Department of Pathology

6. The First Affiliated Hospital of Fujian Medical University

7. Fuzhou 350005

8. Department of Pharmaceutical Analysis

9. Faculty of Pharmacy

10. Fujian Medical University

11. Fuzhou 350108

12. Department of Clinical Laboratory

Abstract

We developed a DNA sensor for the precise detection of point mutation of K-ras gene. The sensor was based on DNA replication, which employed the DNA polymerase I and the principle of base pairing, and can detect target DNA in mixture sample.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA24737C

Reference21 articles.

1. The Epidemiology of Pancreatitis and Pancreatic Cancer

2. Pancreatic cancer

3. Do Early Symptoms of Pancreatic Cancer Exist that Can Allow an Earlier Diagnosis?

4. Surgical Treatment of Pancreatic Cancer

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