Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening-Reference-Cited by-同舟云学术

Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening

Published:2016 Issue:9 Volume:12 Page:2713-2721
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Chong Cheong-Meng¹²³⁴⁵,Kou Man-Teng¹²³⁴⁵,Pan Peichen⁶⁷⁸⁵,Zhou Hefeng¹²³⁴⁵,Ai Nana¹²³⁴⁵,Li Chuwen¹²³⁴⁵,Zhong Hai-Jing¹²³⁴⁵,Leung Chung-Hang¹²³⁴⁵,Hou Tingjun⁶⁷⁸⁵⁹,Lee Simon Ming-Yuen¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. and Institute of Chinese Medical Sciences

3. University of Macau

4. Macao

5. China

6. College of Pharmaceutical Sciences

7. Zhejiang University

8. Hangzhou

9. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices

Abstract

Through the combined virtual and high content drug screening, BIPM was identified as a novel and potent ROCK2 inhibitor. Exposure of SH-SY5Y cells to BIPM led to significant changes in neurite length, cell migration and actin stress fibers via mediating ROCK2 downstream proteins.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MB/C6MB00343E

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