Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams-Reference-Cited by-同舟云学术

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Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams

Published:2017 Issue:2 Volume:8 Page:1607-1612
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Saha Subhasish¹²³⁴⁵,Zhang Wenjun¹²³⁴⁵,Zhang Guangtao¹²³⁴⁵,Zhu Yiguang¹²³⁴⁵,Chen Yuchan⁶⁷⁸⁹,Liu Wei¹²³⁴⁵,Yuan Chengshan¹²³⁴⁵,Zhang Qingbo¹²³⁴⁵,Zhang Haibo¹²³⁴⁵,Zhang Liping¹²³⁴⁵,Zhang Weimin⁶⁷⁸⁹,Zhang Changsheng¹²³⁴⁵^ORCID

Affiliation:

1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology

2. Guangdong Key Laboratory of Marine Materia Medica

3. South China Sea Institute of Oceanology

4. Chinese Academy of Sciences

5. Guangzhou 510301

6. State Key Laboratory of Applied Microbiology Southern China

7. Guangdong Institute of Microbiology

8. Guangzhou 510070

9. China

Abstract

We report the activation of a PTM gene cluster in marine-derived Streptomyces pactum, leading to the discovery of six new PTMs, the pactamides A-F.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03875A

Reference33 articles.

1. Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams

2. Alteramide A, a new tetracyclic alkaloid from a bacterium Alteromonas sp. associated with the marine sponge Halichondria okadai

3. Structure and Biosynthesis of Heat-Stable Antifungal Factor (HSAF), a Broad-Spectrum Antimycotic with a Novel Mode of Action

4. Bioactive Polycyclic Tetramate Macrolactams from Lysobacter enzymogenes and Their Absolute Configurations by Theoretical ECD Calculations

5. Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria

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