Integrated microfluidic system for cell co-culture and simulation of drug metabolism-Reference-Cited by-同舟云学术

Integrated microfluidic system for cell co-culture and simulation of drug metabolism

Published:2016 Issue:59 Volume:6 Page:54564-54572
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Jie Mingsha¹²³⁴⁵,Li Hai-Fang⁵⁶⁷⁸⁹,Lin Luyao⁵⁶⁷⁸⁹,Zhang Jie⁵⁶⁷⁸⁹,Lin Jin-Ming⁵⁶⁷⁸⁹

Affiliation:

1. State Key Laboratory of Chemical Resource Engineering

2. Beijing University of Chemical Technology

3. Beijing 100029

4. China

5. Department of Chemistry

6. Beijing Key Laboratory of Microanalytical Methods and Instrumentation

7. The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology

8. Tsinghua University

9. Beijing 100084

Abstract

We present a microfluidic integrator for cell cocultivation and simulation of pharmaceutical kinetic processes of oral drugs including intestinal absorption, liver metabolism, and anticancer activity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA10407J

Reference42 articles.

1. Predicting drug metabolism: experiment and/or computation?

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4. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

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