Sometimes less is more—the impact of the number of His residues on the stability of Zn(ii)–SmtB and BigR4 α-5 domain complexes

Author:

Rola Anna1,Wieczorek Robert1,Kozłowski Henryk2,Krzywoszyńska Karolina2,Potocki Sławomir1ORCID

Affiliation:

1. Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14 St, 50-383 Wroclaw, Poland

2. Institute of Health Sciences, University of Opole, Katowicka 68 St, 45-060 Opole, Poland

Abstract

The formation equilibria of zinc(ii) complexes of the α5 binding domain of SmtB/BigR4 proteins and mutants of the latter are studied and an unusual behaviour of histidine ligands is observed.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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