Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics-Reference-Cited by-同舟云学术

Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics

Published:2014 Issue:7 Volume:31 Page:905-923
ISSN:0265-0568
Container-title:Nat. Prod. Rep.
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Li Bo¹²³,Wever Walter J.⁴⁵²³,Walsh Christopher T.⁶⁷⁸,Bowers Albert A.⁴⁵²³

Affiliation:

1. Department of Chemistry

2. University of North Carolina at Chapel Hill

3. Chapel Hill

4. Division of Chemical Biology and Medicinal Chemistry

5. Eshelman School of Pharmacy

6. Department of Biological Chemistry and Molecular Pharmacology

7. Harvard Medical School

8. Boston

Abstract

Dithiolopyrrolone natural products have unique structures and exhibit a broad-spectrum of antimicrobial and anticancer activities. Isolated in the late 1940s, these molecules have attracted an increasing interest towards their biosynthesis, synthesis and mechanisms of action.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/NP/C3NP70106A

Reference88 articles.

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2. The crystal and molecular structure of a sulphur-containing antibiotic, `vD844', 5-oxo-6-N-methylformylamino-4,5-dihydro-1,2-dithiolo[4,3-b]pyrrole

3. NEW ANTIBIOTICS CONTAINING THE 1, 2-DITHIOLO[4, 3-b]PYRROLE RING SYSTEM

4. ISOLATION OF A NEW ANTIBIOTIC SUBSTANCE, AUREOTHRICIN FROM A STRAIN OF STREPOMYCES

5. CHARACTERIZATION OF THE ANTIBIOTIC THIOLUTIN AND ITS RELATIONSHIP WITH AUREOTHRICIN

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