Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling <i>in vitro</i> and <i>in vivo</i> blood–brain barrier transport-Reference-Cited by-同舟云学术

Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling in vitro and in vivo blood–brain barrier transport

Published:2024 Issue:15 Volume:15 Page:7812-7827
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Carecho Rafael¹²^ORCID,Marques Daniela¹,Carregosa Diogo¹^ORCID,Masuero Domenico³,Garcia-Aloy Mar³^ORCID,Tramer Federica⁴,Passamonti Sabina⁴,Vrhovsek Urska³,Ventura M. Rita²^ORCID,Brito Maria Alexandra⁵⁶,Nunes dos Santos Cláudia¹²⁷^ORCID,Figueira Inês¹^ORCID

Affiliation:

1. iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, Lisboa, Portugal

2. Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Avenida da República, Oeiras, Portugal

3. Metabolomics Unit, Research and Innovation Centre, Fondazione Edmund Mach (FEM), via E. Mach 1, San Michele all'Adige, Italy

4. Department of Life Sciences, University of Trieste, via L. Giorgieri 1, Trieste, Italy

5. Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa, Portugal

6. Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa, Portugal

7. iBET, Instituto de Biologia Experimental e Tecnológica, Avenida da República, Apartado 12, Oeiras, Portugal

Abstract

Circulating metabolites resulting from colonic metabolism of dietary (poly)phenols are highly abundant in the bloodstream, though still marginally explored, particularly concerning their brain accessibility.

Funder

Fundação para a Ciência e a Tecnologia

European Regional Development Fund

HORIZON EUROPE European Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO01396D

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