Synthesis of new betulinic acid–peptide conjugates and in vivo and in silico studies of the influence of peptide moieties on the triterpenoid core activity-Reference-Cited by-同舟云学术

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Synthesis of new betulinic acid–peptide conjugates and in vivo and in silico studies of the influence of peptide moieties on the triterpenoid core activity

Published:2015 Issue:1 Volume:6 Page:230-238
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Govdi Anastasiya I.¹²³⁴,Sokolova Nadezda V.⁵⁶⁷⁴,Sorokina Irina V.⁸²³⁴,Baev Dmitry S.⁸²³⁴,Tolstikova Tatyana G.⁸²³⁴,Mamatyuk Victor I.⁸²³⁴,Fadeev Dmitry S.⁸²³⁴,Vasilevsky Sergey F.¹²³⁴⁸,Nenajdenko Valentine G.⁵⁶⁷⁴⁹

Affiliation:

1. Institute of Chemical Kinetics and Combustion

2. Siberian Branch of the Russian Academy of Sciences

3. Novosibirsk

4. Russia

5. Department of Chemistry

6. Moscow State University

7. Moscow

8. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

9. A. N. Nesmeyanov Institute of Organoelement Compounds

Abstract

Betulinic acid–peptide conjugates exhibit high anti-inflammatory activity.

Funder

Russian Foundation for Basic Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00236A

Reference41 articles.

1. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

2. Biological activity and pharmacological prospects of lupane terpenoids: II. Semisynthetic lupane derivatives

3. Biological Activity of Betulinic Acid: A Review

4. Pharmacological properties of the ubiquitous natural product betulin

5. Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins

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2. Peptide–Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics;Journal of Medicinal Chemistry;2024-01-26

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4. Enhanced Cytotoxicity and Antimelanoma Activity of Novel Semisynthetic Derivatives of Betulinic Acid with Indole Conjugation;Plants;2023-12-21

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