Orally administered bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy-Reference-Cited by-同舟云学术

Orally administered bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy

Published:2022 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Runming¹^ORCID,Chan Jasper Fuk-Woo²³⁴⁵⁶,Wang Suyu¹,Li Hongyan¹^ORCID,Zhao Jiajia⁷,Ip Tiffany Ka-Yan¹,Zuo Zhong⁷^ORCID,Yuen Kwok-Yung²³⁴⁵⁶,Yuan Shuofeng²³⁶^ORCID,Sun Hongzhe¹^ORCID

Affiliation:

1. Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Hong Kong SAR, P. R. China

2. State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

3. Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China

4. Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

5. Academician Workstation of Hainan Province, Hainan Medical University, Haikou, Hainan, China

6. Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, China

7. School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China

Abstract

A cocktail therapy comprising bismuth drugs and N-acetyl-l-cysteine is reported to suppress the replication of SARS-CoV-2 via the oral route. The broad-spectrum inhibitory activities of the combination upon key viral cysteine enzymes are verified.

Funder

Research Grants Council, University Grants Committee

Innovation and Technology Fund

Food and Health Bureau

Innovation and Technology Commission

National Key Research and Development Program of China

Sanming Project of Medicine in Shenzhen

Major Science and Technology Project of Hainan Province

University of Hong Kong

Hui Hoy and Chow Sin Lan Charity Fund

Hong Kong Hainan Commercial Association

Jessie and George Ho Charitable Foundation

Lo Ying Shek Chi Wai Foundation

Health and Medical Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC04515F

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