Photochemical synthesis of an epigenetic focused tetrahydroquinoline library-Reference-Cited by-同舟云学术

Photochemical synthesis of an epigenetic focused tetrahydroquinoline library

Published:2021 Issue:10 Volume:12 Page:1780-1786
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Green Adam I.¹,Burslem George M.¹²^ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA

2. Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA

Abstract

This work describes the photochemical synthesis of a tetrahydroquinoline library enriched with chemotypes privileged for epigenetic targets and exploring new regions of chemical space.

Funder

National Science Foundation

Vagelos Institute for Energy Science and Technology, University of Pennsylvania

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00193K

Reference36 articles.

1. Principles of early drug discovery

2. Evolution of commercially available compounds for HTS

3. Where Do Recent Small Molecule Clinical Development Candidates Come From?

4. Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres

5. Predicted Biological Activity of Purchasable Chemical Space

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