Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction-Reference-Cited by-同舟云学术

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Published:2018 Issue:80 Volume:54 Page:11316-11319
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Galman James L.¹²³^ORCID,Slabu Iustina¹²³^ORCID,Parmeggiani Fabio¹²³^ORCID,Turner Nicholas J.¹²³^ORCID

Affiliation:

1. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street

2. Manchester

3. UK

Abstract

A novel multi-enzymatic approach enabled the facile synthesis of a broad range of biologically active 2-substituted piperidine and pyrrolidine alkaloids.

Funder

Seventh Framework Programme

Biotechnology and Biological Sciences Research Council

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC06759G

Reference26 articles.

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3. P. M. Dewick , Medicinal Natural Products , John Wiley & Sons Ltd. , Chichester, UK , 2013

4. R. Vardanyan , Classes of Piperidine-Based Drugs , in Piperidine-Based Drug Discovery , Elsevier , 2018 , (ch. 10)

5. Proline catalyzed, one-pot three component Mannich reaction and sequential cyclization toward the synthesis of 2-substituted piperidine and pyrrolidine alkaloids

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