Isolation of cytotoxic daphnane-type and tigliane-type diterpenoids from Daphne genkwa using MetGem software

Author:

Mi Si-Hui1,Duan Zhi-Kang1,Wang Yu-Jue1,Dong Shu-Hui1,Zhao Peng1,Yao Guo-Dong1,Liu Qing-Bo1,Lin Bin2,Song Shao-Jiang1ORCID,Huang Xiao-Xiao1ORCID

Affiliation:

1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China

2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China

Abstract

Guided by MetGem Molecular Networking, eight daphnane-type and tigliane-type diterpenoids including four undescribed compounds were isolated from Daphne genkwa.

Funder

Liaoning Revitalization Talents Program

National Natural Science Foundation of China

Key Research and Development Program of Liaoning Province

Department of Education of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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