Direct synthesis of chiral β-arylamines <i>via</i> additive-free asymmetric reductive amination enabled by tunable bulky phosphoramidite ligands-Reference-Cited by-同舟云学术

Direct synthesis of chiral β-arylamines via additive-free asymmetric reductive amination enabled by tunable bulky phosphoramidite ligands

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Jing¹,Wang Wenji¹,Huang Haizhou¹,Ma Zhiqing²^ORCID,Chang Mingxin¹²^ORCID

Affiliation:

1. College of Chemistry & Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, PR China

2. College of Plant Protection, Shaanxi Research Center of Biopesticide Engineering & Technology, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, PR China

Abstract

An additive-free asymmetric reductive amination for efficient chiral β-arylamine synthesis is described. Bulky and tunable phosphoramidite ligands enable excellent enantiomeric control, even for alkylamines which lack secondary coordinating sites.

Funder

Natural Science Basic Research Program of Shaanxi Province

National Natural Science Foundation of China

Northwest A and F University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC04416A

Reference45 articles.

1. M.Qureshi and J.Njardarson , Compiled and produced by the Njardarson group , The University of Arizona , 2022

2. Chiral Amine Synthesis: Methods, De-velopments and Applications , ed. T. Nugent , Wiley-VCH , Weinheim , 2010

3. W.Li , X.Zhang , Stereoselective Formation of Amines , Springer , Berlin, Heidelberg , 2014 , vol. 343

4. New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines

5. Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines