Role of antibody heavy and light chain interface residues in affinity maturation of binding to HIV envelope glycoprotein-Reference-Cited by-同舟云学术

Role of antibody heavy and light chain interface residues in affinity maturation of binding to HIV envelope glycoprotein

Published:2019 Issue:4 Volume:4 Page:737-746
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Cisneros Alberto¹²³⁴⁵,Nargi Rachel Stecker¹²³⁴,Parrish Erica Hammaker¹²³⁴,Haliburton Christian Marie¹²³⁴,Meiler Jens⁶⁷⁸³⁴,Crowe Jr. James E.¹²³⁴⁵^ORCID

Affiliation:

1. The Vanderbilt Vaccine Center

2. Vanderbilt University Medical Center

3. Nashville

4. USA

5. Chemical and Physical Biology Program

6. Department of Chemistry

7. Center for Structural Biology

8. Vanderbilt University

Abstract

Optimization of the heavy chain/light chain interface could serve as an important tool for maximizing antibody/antigen binding affinity without altering antigen contact residues.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2019/ME/C8ME00080H

Reference44 articles.

1. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

2. Human Germline Antibody Gene Segments Encode Polyspecific Antibodies

3. The association of heavy and light chain variable domains in antibodies: implications for antigen specificity

4. Analysis and prediction of VH/VL packing in antibodies

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