Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy
Author:
Affiliation:
1. Centre for Misfolding Diseases
2. Department of Chemistry
3. University of Cambridge
4. Cambridge CB2 1EW
5. UK
Abstract
A structural ensemble derived from cryo-electron microscopy reveals a cryptic pocket site in intermediate states along the opening pathway of the SARS-CoV-2 spike protein.
Funder
Federation of European Biochemical Societies
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00244A
Reference38 articles.
1. The proximal origin of SARS-CoV-2
2. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
3. Structure, Function, and Evolution of Coronavirus Spike Proteins
4. Site-specific glycan analysis of the SARS-CoV-2 spike
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