Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequences-Reference-Cited by-同舟云学术

Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequences

Published:2017 Issue:2 Volume:8 Page:1658-1664
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Raibaut Laurent¹²³⁴⁵,Vasseur William¹²³⁴⁵,Shimberg Geoffrey D.⁶⁷⁸⁹¹⁰,Saint-Pierre Christine¹¹¹³⁴¹²,Ravanat Jean-Luc¹¹¹³⁴¹²,Michel Sarah L. J.⁶⁷⁸⁹¹⁰,Sénèque Olivier¹²³⁴⁵

Affiliation:

1. Univ. Grenoble Alpes

2. LCBM/PMB

3. F-38000 Grenoble

4. France

5. CNRS

6. Department of Pharmaceutical Sciences

7. School of Pharmacy

8. University of Maryland

9. Baltimore

10. USA

11. INAC-SyMMES

12. CEA

Abstract

We report the design of a luminescent sensor based upon the zinc finger protein TIS11d, that allows for the selective time-resolved detection of the UUAUUUAUU sequence of the 3′-untranslated region of messenger RNA.

Funder

National Science Foundation

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC04086A

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