Structure–functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators-Reference-Cited by-同舟云学术

Structure–functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators

Published:2017 Issue:21 Volume:15 Page:4620-4630
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kamal Ahmed A. M.¹²³⁴^ORCID,Petrera Lucia¹²³⁴,Eberhard Jens¹²³⁴,Hartmann Rolf W.¹²³⁴⁵

Affiliation:

1. Helmholtz-Institute for Pharmaceutical Research Saarland

2. Department of Drug Design and Optimization

3. 66123 Saarbrücken

4. Germany

5. Department of Pharmacy

Abstract

Alkylquinolone derived compounds revealed four pharmacological profiles for PqsR modulation. Molecular docking illuminated the structural requirements. Only inverse agonists were effective pathoblockers inhibiting pyocyanin.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00263G

Reference51 articles.

1. Antibacterial-Resistant Pseudomonas aeruginosa : Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms

2. Hospital-Acquired Infections Due to Gram-Negative Bacteria

3. Overview of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> and Novel Therapeutic Approaches

4. Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

5. Targeting virulence: a new paradigm for antimicrobial therapy

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Indazole–Quinolone Hybrids as Anti-Virulence Agents against Pseudomonas aeruginosa;Drugs and Drug Candidates;2024-07-19

2. Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?;International Journal of Nanomedicine;2024-04

3. Multidimensional Criteria for Virtual Screening of PqsR Inhibitors Based on Pharmacophore, Docking, and Molecular Dynamics;International Journal of Molecular Sciences;2024-02-03

4. Formation of 5-Aminomethyl-2,3-dihydropyridine-4(1H)-ones from 4-Amino-tetrahydropyridinylidene Salts;Molecules;2023-09-29

5. Structural modification of the Pseudomonas aeruginosa alkylquinoline cell–cell communication signal, HHQ, leads to benzofuranoquinolines with anti-virulence behaviour in ESKAPE pathogens;Microbiology;2023-03-02